The latest COVID-19 conundrum is when to get another shot

It seems intuitively fair that a reformulated booster vaccine targeting the omicron BA.5 variant would dramatically improve our protection against it as well as any progeny that may threaten us in the fall. But intuition does not always agree with scientific data.

It is not at all intuitive to think that waiting six months before being boosted significantly improves protection. Yet that’s what the data shows, and it’s starting to make sense to a few researchers studying under the hood how our immune system works and what it’s capable of, given enough time.

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